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Cynthia "Cindy" Rowe, Ph.D.
UM Researcher’s Team Explores the Power of Families to Halt Underage Drinking

When the Surgeon General asserted that teen drinking remained one of the nation's most serious public health problems, he called on parents, guardians and experts in teen interventions to treat the matter with urgency.

That was in 2007, when Cynthia "Cindy" Rowe, Ph.D., associate professor of epidemiology and public health, was marking her eleventh year at the Miller School. Working with mentors who were international experts in child psychology and adolescent drug abuse, she had become well-versed in Multidimensional Family Therapy (MDFT), an internationally accepted treatment for adolescent substance abuse that may also help curtail teen drinking.

Pioneered by Rowe's mentor, Howard Liddle, Ed.D., Multidimensional Family Therapy is practiced through training agreements with institutions in several U.S. states and European countries. Liddle, professor of epidemiology and public health, and director of the Miller School-based Center for Treatment Research on Adolescent Drug Abuse, developed the family-based intervention 25 years ago.

Like other members of the MDFT team, Rowe has helped train other counselors locally and abroad to use MDFT for substance abuse intervention. She says knowing she has helped "build stronger families during some of the most difficult times" has brought a sense of personal satisfaction.

Now, armed with a five-year, $3,275,536 grant from the National Institutes of Health/ National Institute on Alcohol Abuse and Alcoholism, Rowe and her team are answering the Surgeon General's call and will conduct a randomized trial to test MDFT and another family intervention for adolescent alcohol problems.

"Research was showing that, in addition to well-known problems with drugs, many kids were engaging in binge drinking, getting very drunk, getting into fights or accidents -- life-threatening behaviors,'' says Rowe, who won the grant based on the results of a promising pilot study. "So for many years we wanted to do a study that focused on helping kids who have trouble with drinking. Family-based treatments have proven very effective for adolescent drug abuse, but they have not been studied extensively with kids who are primarily drinking.

"It's sort of an odd thing,'' she continues. "You wouldn't think there would be such a disconnect in studying teens with drug problems and teens with drinking problems, but in the research field there is actually quite a disconnect. Part of the problem is that finding the teens who are primarily alcohol abusers has been difficult."

Rowe resolved that problem in her pilot study by identifying alcohol-abusing teens and their families in the emergency room. The location, she says, proved productive because teen drinkers often wind up at the hospital after a fight, car accident, or other brush with danger. The setting also created an ideal opportunity to engage kids and parents in MDFT because traumatic episodes are scary, motivating family members to ensure the adolescent seeks help.

The new study will recruit 250 adolescents, ages 12 to 18, and their families from the ER at Jackson Memorial Hospital and Miami Children's Hospital. Expanding on the pilot study, adolescents identified with risk for alcohol abuse will be randomly assigned to one of three different interventions: standard care, Family Motivational Interviewing Intervention (FMII), or the more intensive MDFT.

Both MDFT and FMII aim to enhance the influence of the family to motivate and help youth change, but rely on different theoretical foundations and clinical techniques. Both will provide two initial engagement sessions in the homes of participants within 72 hours of the ER visit. Thereafter, MDFT participants will be enrolled in a three-month course of this family-centered treatment, while FMII participants will undergo three months of standard group treatment.

In the standard-care intervention, teens will be referred to the same group treatment as the FMII group, but will not receive engagement or family sessions. Results will be compared after three, six, nine, 12 and 18 months to garner retention rates, clinical outcomes and cost-effectiveness.

"Usually, for substance abuse, the most cost-effective and efficient approach is to identify the kids young enough who are the highest risk, and intervene with models that work,'' Rowe says. "Treatments such as MDFT work with the family to strengthen parenting, to help the parents who are often overburdened with their own stress, and deal with other issues, such as problems in school, that often go hand-in-hand with teen substance abuse. When families are provided these resources and skills, we begin to see the power of the family. Rather than blaming each other, family members begin working together to deal with their problems."

And it's the evidence that shows teens can change in incredible ways when families come together that has made MDFT internationally accepted, and has cemented Rowe's commitment to this clinical research program. A student of this form of therapy since her graduate school days at Temple University - home of the Liddle team before it moved to the Miller School in 1996 - Rowe completed her Ph.D. under Liddle and Gayle Dakof, Ph.D., research associate professor in epidemiology and public health. She went on to a one-year clinical psychology internship at Jackson Memorial Hospital.

"Drs. Liddle and Dakof are not only great researchers, they are also great clinicians," Rowe notes. "This is very rare. Their combination of skills and experience brings such balance to our team, and that's one of the reasons our team stands out in this area of research."

It's also why, as their study abstract says, Rowe and her team now have the potential to guide providers and policy makers to implement the most effective and cost-beneficial alcohol intervention for youth, and to halt the progression of alcohol problems in susceptible adolescents.

Grand Rounds
Tuesday, December 01, 2009 8 a.m.
Pediatric Grand Rounds: “Update on Inflammatory Bowel Disease”
Tuesday, December 01, 2009 12 p.m.
Cardiovascular Grand Rounds: “Predicting and Preventing Stroke”
Wednesday, December 02, 2009 7:30 a.m.
Plastic Surgery Grand Rounds: “Minimizing Scars and Keloids – Update”
Wednesday, December 02, 2009 11:45 a.m.
Dermatology and Cutaneous Surgery Grand Rounds: "Catalyzing Health Care Transformation Via TeleHealth"
Thursday, December 03, 2009 6:45 a.m.
Anesthesiology Grand Rounds: "Controversies in Perioperative Pacemaker and Defibrillator Management"
Thursday, December 03, 2009 7 a.m.
Neurological Surgery Grand Rounds
Thursday, December 03, 2009 7 a.m.
Orthopaedic Grand Rounds: “Mobile Bearing Total Knee Replacement”
Thursday, December 03, 2009 7:30 a.m.
Surgical Grand Rounds/Barbara B. Williams Lecture: “Laparoscopic Liver Resection for Cancer”
Thursday, December 03, 2009 8 a.m.
Otolaryngology Grand Rounds: “Facial Reanimation”
Thursday, December 03, 2009 12 p.m.
Pathology Grand Rounds: “On Social Entrepreneurship – There is Life Outside of Pathology”
Friday, December 04, 2009 10 a.m.
Neurology Grand Rounds
Friday, December 04, 2009 12 p.m.
Psychiatry Grand Rounds: “Medical Errors Prevention, Part One”
Tuesday, December 08, 2009 8 a.m.
Pediatric Grand Rounds: “Facial Clefting and Reconstruction”
Tuesday, December 08, 2009 12 p.m.
Cardiovascular Grand Rounds
Thursday, December 10, 2009 7 a.m.
Orthopaedic Grand Rounds: "Proximal Opening Wedge Osteotomy of the First Metatarsal with Plate Fixation for Hallux Valgus"
Thursday, December 10, 2009 7:30 a.m.
Surgical Grand Rounds: “Malpractice Lawsuit Prevention”
Thursday, December 10, 2009 8 a.m.
Neurological Surgery Grand Rounds: “Neuropathology Review Conference”
Thursday, December 10, 2009 8 a.m.
Otolaryngology Grand Rounds: “Allergic Rhinitis”
Thursday, December 10, 2009 12 p.m.
Hospital Medicine Grand Rounds: “Understanding Enteral/Parenteral Nutrition - 2009”
Friday, December 11, 2009 10 a.m.
Neurology Grand Rounds: “Searching for New Approaches to Prevent Stroke”
Tuesday, December 15, 2009 8 a.m.
Pediatric Grand Rounds: "The Pathogenesis of Staphylococcus Aureus Pneumonia and the Role of Immunity"
Tuesday, December 15, 2009 12 p.m.
Cardiovascular Grand Rounds: “Chronic Kidney Disease: Can We Reduce Cardiovascular Risk?”
Thursday, December 17, 2009 7 a.m.
Orthopaedic Grand Rounds: “Thumb Carpometacarpal Joint Arthritis”
Thursday, December 17, 2009 7:30 a.m.
Surgical Grand Rounds: “Percutaneous Treatment of Aortic Valve Disease”
Thursday, December 17, 2009 8 a.m.
Neurological Surgery Grand Rounds: “Neuropathology”
Friday, December 18, 2009 10 a.m.
Neurology Grand Rounds: “Movement Disorders of Childhood”
Friday, December 18, 2009 12 p.m.
Psychiatry Grand Rounds: “Culturally-Informed Therapy for Schizophrenia”
Friday, December 18, 2009 3 p.m.
Medicine Grand Rounds: “Clinical Pharmacogenomics in Clinical Practice”
Tuesday, December 29, 2009 8 a.m.
Pediatric Grand Rounds: “TB 2009: A Perspective From Chile”
Thursday, December 31, 2009 12 p.m.
Hospital Medicine Grand Rounds: “Thrombocytopenia in the Clinical Setting - 2009”
Events
Tuesday, December 01, 2009 11 a.m. Student Members of Physicians for Human Rights Commemorate World AIDS Day with Awareness Campaign
Tuesday, December 01, 2009 12 p.m. Cell Biology and Anatomy Seminar: “Probing Mitochondrial DNA Structure with Mitochondria-Targeted DNA Methyltransferases"
Tuesday, December 01, 2009 4 p.m. Genetics and Genomics Seminar: “miRNAs, Morphology and Metastasis”
Wednesday, December 02, 2009 11:59 a.m. Gail F. Beach Memorial Visiting Lectureship: “Applications of Recurrent Brain-Computer Interfaces”
Thursday, December 03, 2009 7 a.m. Continuing Medical Education Course: "An Update in the Management of Pediatric Growth Hormone Deficiency"
Thursday, December 03, 2009 12 p.m. Microbiology and Immunology Seminar: "Hyperoxic Reversal of Hypoxia-Adenosinergic Immunosuppression in Lung Metastases"
Friday, December 04, 2009 12 p.m. Friday Noon Interdisciplinary Lecture Series/First Fridays Talks on Autism: "Toilet Training Individuals with Autism"
Friday, December 04, 2009 12 p.m. Neuroscience Center Seminar: "Control of Ion Channel Modulation, Synaptic Plasticity and Neuronal Circuits by Light"
Friday, December 04, 2009 12 p.m. Biochemistry and Molecular Biology Seminar: “Nucleosome Dynamics During DNA Replication and Repair”
Saturday, December 05, 2009 7 a.m. Bascom Palmer Presents: “Retinal and Glaucoma Imaging 2010”
Saturday, December 05, 2009 7:29 a.m. Advances in Flexible Endoscopy Course
Monday, December 07, 2009 12 p.m. Microbiology and Immunology Seminar: "TNFRSF25 Robustly Expands CD4+Foxp3+ Regulatory T Cells In Vivo"
Tuesday, December 08, 2009 9 a.m. DMAS/FRS Training Scheduled for December
Wednesday, December 09, 2009 9 a.m. The Miami Project to Cure Paralysis Seminar
Wednesday, December 09, 2009 12 p.m. Microbiology and Immunology Dissertation Seminar: “APRIL (TNFSF13) in Th1, Th2 and Th17 Responses”
Wednesday, December 09, 2009 12 p.m. Pediatric Clinical Research Forum: “Viral Time Bomb: Pediatric HCV in the State of Florida”
Thursday, December 10, 2009 10 a.m. The Buoniconti Fund to Cure Paralysis Hosts First Holiday Bazaar
Thursday, December 10, 2009 11:30 a.m. Israeli Health Care Reform Symposium
Thursday, December 10, 2009 12 p.m. Microbiology and Immunology Seminar: "Immunoglobulin Class Switch DNA Recombination and Somatic Hypermutation"
Thursday, December 10, 2009 12 p.m. Molecular and Cellular Pharmacology Seminar: “Stem Cells and Cardiomyogenesis”
Thursday, December 10, 2009 12 p.m. NIH Update Meeting
Thursday, December 10, 2009 3 p.m. Department of Medicine Seminar
Thursday, December 10, 2009 4 p.m. Miller School Dean Pascal J. Goldschmidt, M.D., to Present the 10th Biennial Gross Lecture
Friday, December 11, 2009 12 p.m. Biochemistry and Molecular Biology Seminar: "Recognition and Repair of UV-Induced DNA Damage in the Context of Chromatin"
Sunday, December 13, 2009 8:30 a.m. Walk/Run to Benefit the Diabetes Research Institute
Monday, December 14, 2009 12 p.m. Microbiology and Immunology Seminar: “Unraveling Confused CTL”
Tuesday, December 15, 2009 9 a.m. Molecular and Cellular Pharmacology Dissertation Seminar: "Vav3 Potentiation of Androgen Receptor Activity in Prostate Cancer"
Tuesday, December 15, 2009 12 p.m. Cell Biology and Anatomy Seminar: "New Perspective for ORF Phage Display as an Efficient Versatile Technology of Functional Proteomics"
Tuesday, December 15, 2009 1 p.m. Molecular and Cellular Pharmacology Special Seminar: "Androgen Receptor Corepressor NCoR is a Key Regulator of Androgen Receptor Action in Prostate Cancer"
Tuesday, December 15, 2009 4 p.m. Genetics and Genomics Seminar: "Next-Generation Sequencing: Novel Applications for Molecular Genetics"
Thursday, December 17, 2009 12 p.m. Molecular and Cellular Pharmacology Seminar: “Early Detection of Melanoma by Olfactory Receptors”
Thursday, December 17, 2009 1:15 p.m. Department of Medicine Seminar: “HIV Persistence in the Face of HAART”
Friday, December 18, 2009 11 a.m. Neurology Clinicopathological Conference
Friday, December 18, 2009 12 p.m. Biochemistry and Molecular Biology Seminar: "Common Variants in Innate Immunity Genes Influence Susceptibility to Pulmonary Tuberculosis in Three Populations"
Friday, December 18, 2009 1 p.m. Neuroscience Center Seminar: "Calcium, Selective Neurodegeneration and Protection in Parkinson's Disease"
Friday, December 18, 2009 3 p.m. Liberty City Toy Drive
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